Discover Novel Therapeutic Strategies for Peritoneal Metastases from Gastric Adenocarcinoma

Abstract

Through this grant we have not only published 4 high-impact papers, we identified cancer stem cells role in aggressive behavior of peritoneal carcinomatosis. We have developed new cell lines and animal models. We identified which oncogene (Yap1) drives peritoneal carcinomatosis and we could reduce the incidence of peritoneal metastases. We have extensively characterized PDX models and cell lines (these will be useful resources to the oncology community). We have accomplished single cell sequencing in 20 patients with unique results to be published in Nature Medicine. Discovered crosstalk between TRIM28 and Yap1 (potentially both can be exploited in the clinic). We have defined proteomics of peritoneal cells at the mass spect level (never been reported for gastric cancer) and defined mRNAs as well a unique long-non-coding RNA (CCAT2) that regulated chromosomal instability. We are now poised to take our discoveries to the next level.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2020
Accession Number
AD1130917

Entities

People

  • George A. Calin

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Abdomen
  • Adenocarcinoma
  • Biology
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Clinical Trials
  • Computational Biology
  • Data Analysis
  • Gene Expression
  • Genetic Engineering
  • Health Services
  • Information Science
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Proteins
  • Proteomics
  • Statistical Analysis
  • Stem Cells
  • Systems Biology
  • Therapy

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology