TRACK-TBI Precision Medicine - Pathomechanistic Classification of Traumatic Brain Injury: The Bridge to Targeted Therapies

Abstract

TRACK-TBI Precision Medicine utilizes the rich TRACK-TBI dataset to validate biomarkers of diffuse axonal injury (DAI), microvascular injury (MVI), and neuro-inflammation using advanced blood-based assay platforms and MRI sequences. The project will validate early and ultra-early blood-based and imaging biomarkers of DAI, MVI, and neuro-inflammation and will conduct a multicenter, double-blind, placebo-controlled exploratory clinical trial comparing the impact of cyclosporine A on blood-based and imaging biomarkers of DAI and neuro-inflammation in moderate/severe TBI patients.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1132253

Entities

People

  • Amy J. Markowitz
  • Brian Fabian
  • Geoffrey T. Manley

Organizations

  • University of California, San Francisco

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Brain Injuries
  • Cardiovascular System
  • Chemistry
  • Cognitive Impairment
  • Demography
  • Employment
  • Health Services
  • Magnetic Resonance
  • Medical Personnel
  • Mobile Phones
  • Neuroimaging
  • Patient Care
  • Personnel Management
  • Proteins
  • Statistical Analysis
  • Therapy
  • Traumatic Stress Disorder
  • Vascular System Injuries
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Neurotrauma and Rehabilitation Medicine.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.