Dose and Time Dependent Inhibition of Blood Cholinesterase by Pyridostigmine Bromide in African Green Monkeys

Abstract

Pyridostigmine bromide (PB) is a carbamate drug that can reversibly bind to the enzyme cholinesterase (ChE) and temporarily shield the enzyme from irreversible inhibition by organophosphate nerve agents. PB doses that produce 20-40 inhibition of red blood cell (RBC) ChE have been shown to provide optimal protection against toxicity from nerve agents. As such, PB has been adopted by military forces of several countries as a nerve agent pretreatment to enhance protection provided by standard post-exposure medical countermeasures (atropine, oxime, benzodiazepine anticonvulsant) against nerve agent toxicity. The present study evaluated the dose- and time-dependent changes in blood ChE levels produced by PB in African green monkeys.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2021
Accession Number
AD1133702

Entities

People

  • Connie Clark
  • Jacklyn Evans
  • John H. McDonough
  • Joseph D. Mcmonagle
  • Kathleen Mcavoy
  • Laura Hamilton
  • Mary Ellen Benito
  • Maura V. Pannell
  • Sean Mcavoy

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Anticonvulsants
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Cells
  • Data Analysis
  • Department Of Defense
  • Inhibition
  • Laboratory Animals
  • Medical Countermeasures
  • Medical Personnel
  • Monkeys
  • Nerve Agents
  • Poisoning
  • Pyridostigmine Bromide
  • Rhesus Monkeys
  • Standards
  • Statistical Analysis
  • Therapy
  • Toxicity
  • Toxicology
  • United States
  • Veins
  • Wounds And Injuries

Fields of Study

  • Biology

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology