Mechanism and Potential Treatment of Guillain Barr Syndrome and Related Neuropathy

Abstract

Guillain-Barre Syndrome (GBS) encompasses a group of polyneuropathies of high medical importance that affect mainly the peripheralnervous system (PNS). In the current model of GBS an adaptive immune response to microbial infection is cross-reactive and destructive to theglycosphingolipids in the protective myelin sheath surrounding axons in the PNS. Damage to myelin results in a several types of clinical manifestation. Recovery usually takes place over the course of several months but a significant number of patients have persistent longer term or permanent neural damage. In our nonhuman primate model of GBS spectrum disease triggered by virusinfection we find multiple hallmarks of neural inflammatory disease, damage to the blood-brain barrier, and upregulation of a key cytokine likely important in the induction of neural damage.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2021
Accession Number
AD1133880

Entities

People

  • Antonito T Panganiban

Organizations

  • Tulane National Primate Research Center

Tags

Communities of Interest

  • Energy and Power Technologies
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Artificial Intelligence
  • Artificial Intelligence Software
  • Biomedical Research
  • Blood-Brain Barrier
  • Central Nervous System
  • Computer Vision
  • Computers
  • Convolutional Neural Networks
  • Covid-19
  • Deep Learning
  • Department Of Defense
  • Dimensionality Reduction
  • Guillain-Barre Syndrome
  • Information Science
  • Machine Learning
  • Medical Personnel
  • Nerve Fibers
  • Nervous System
  • Neural Networks
  • Neuropathy
  • Peripheral Nervous System
  • Peripheral Neuropathy
  • Sars
  • Therapy
  • Viruses

Fields of Study

  • Medicine

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Neuroscience

Technology Areas

  • Biotechnology