Prehospital Analgesia Intervention Trial (PAIN)
Abstract
PAIN is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial comparing fentanyl versus sub-dissociative ketamine for mortality outcome differences, safety and analgesia in trauma patients with compensated shock. Specific aims are to determine if, among prehospital trauma patients with compensated shock (Heart Rate (HR)>109or Shock Index (SI)>0.9) and an indication for pain management, treatment with sub-dissociative IV ketamine as compared to IV fentanyl reduces mortality at 24 hours following admission, reduces the frequency of hemodynamic instability or respiratory depression associated with analgesia, decreases total prehospital exposure to opioids, 24-hour exposure to opioids, and anxiety/PTSD screen scores, improves the frequency of complications including opioid use / dependency, anxiety, and PTSD at 6 months, and improves arrival pain control as measured by numerical rating scale (NRS) and/or the critical care pain observation tool (CPOT).
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1134762
Entities
People
- Barbara J. Early
- Jason Lee Sperry
- Laurie Ney Silfies
- Meghan Buck
- Natalie Rogers
Organizations
- University of Pittsburgh