Metabolic control of DC Fate and Function for Breast Cancer Immunotherapy
Abstract
Immunosuppressive microenvironments induced by Treg cells is a major barrier for effective anti-tumor immunity. We recently discovered accumulated gamma delta 1 Treg cells in the human breast tumor microenvironment, which use a novel suppressive mechanism of senescence induction on T cells and DCs in the tumor suppressive microenvironment. Importantly, these senescent T cells and DCs also develop strong suppressive activity. In this application, our subject and purpose is to explore the mechanisms responsible for DC senescence in the tumor microenvironment mediated by breast cancer-derived gamma delta 1 Treg cells, and then develop novel immunotherapeutic strategies against breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2021
- Accession Number
- AD1134765
Entities
People
- Xia Liu
Organizations
- Saint Louis University