Prevention of Post-Traumatic Osteoarthritis with Cdk9 Inhibitors

Abstract

Almost all common joint injuries, especially among military personnel, will become arthritic over 2-10 years. Arthritis poses a major health problem due to severe pain that limits mobility, which leads to obesity, cardio-vascular diseases, diabetes, depression, and eventually an overall decline in health. Based on our latest findings of the underlying causes of PTOA at the molecular and cellular levels, we believe that we can develop a simple and side-effect free intervention to prevent this type of arthritis, by delivering a single shot of our proposed medicine into the injured joint.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1135300

Entities

People

  • Dominik R Haudenschild

Organizations

  • University of California

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • California
  • Chemical Synthesis
  • Chemistry
  • Fabrication
  • High Resolution
  • Intellectual Property
  • Joints (Anatomy)
  • Law
  • Manufacturing
  • Medical Personnel
  • Patent Applications
  • Small Molecules
  • Social Media
  • Spectroscopy
  • Students
  • Toxicity

Fields of Study

  • Medicine

Readers

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