Cold Stored Platelet Early Intervention (CriSP) trial
Abstract
CriSP-TBI is a proposed 3-year open label, single center, randomized trial designed to determine the feasibility, efficacy and safety of urgent release cold stored platelets in blunt injured patients with traumatic brain injury requiring platelet transfusion. Specific aim one is to determine the feasibility, most appropriate study population and primary outcome that will lead to a large multicenter clinical trial designed to evaluate the effectiveness of cold stored platelet early intervention in patients with TBI requiring platelet transfusion. Specific aim two is to determine whether early cold stored platelet transfusion compared to standard platelet transfusion results in improved hemostatic function and clinical outcomes in patients with traumatic brain injury requiring platelet transfusion. Specific aim three is to determine if early cold stored platelet hemostatic function is similar at 1 through 7 days as compared to 8 through 14 days in patients with TBI on antiplatelet therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1135317
Entities
People
- Barbara J. Early
- Jason Lee Sperry
- Laurie Ney Silfies
- Meghan Buck
- Natalie Rogers
Organizations
- University of Pittsburgh