Steroid-Eluting Therapeutic Contact Lens to Treat and Prevent Inflammation and Scarring Following Ocular Trauma

Abstract

Steroids are frequently used in the care of ocular inflammation, for both post injury and postoperative care. In our previous work with the DOD, we developed a dexamethasone-eluting contact lens continuously worn on the eye which dispenses drug for seven days. Here, we seek to perform further efficacy testing, physicochemical characterization of the TCL, and transfer production to a GLP facility, followed by formal biocompatibility testing in a GLP lab. We demonstrated the TCL can prevent retinal vascular leakage in an animal model. Technology transfer to a GLP facility for fabrication has continued.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 01, 2021
Accession Number
AD1135360

Entities

People

  • Joseph B Ciolino

Organizations

  • Schepens Eye Research Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Clinical Trials
  • Contact Lenses
  • Corneal Diseases
  • Department Of Defense
  • Industrial Production
  • Inflammation
  • Institutional Review Board
  • Lenses
  • Light Transmission
  • Maryland
  • Physical Properties
  • Production
  • Professional Development
  • Retinal Diseases
  • Standards
  • Technology Transfer

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Software Engineering
  • Trauma Surgery or Emergency Medicine.