Characterizing Concussion Using Brain Derived Exosomes
Abstract
Traumatic brain injury (TBI) currently afflicts 357,000 enlisted military men and women in the US Armed Services. For the most common form of TBI, Mild Traumatic Brain Injury (mTBI) most patients recover within a year following the incident, but 10-20 percent of mild cases result in a long-term disability including seizures and emotional and behavioral issues. Although much has been learned about molecular changes in the brain following injury, access to these biomarkers following mTBI is lacking. The accurate diagnosis and precise individual clinical management of traumatic brain injury (TBI) is limited by the lack of accessible molecular biomarkers that are informative regarding the unique mixture of injury mechanisms in each TBI patient.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2021
- Accession Number
- AD1135366
Entities
People
- Danielle Sandsmark
- Dave Meaney
- David Issadore
- Ramon Diaz-Arrastia
Organizations
- University of Pennsylvania