Blocking Tumor-Associated Macrophages to Overcome Chemoresistance in Ovarian Cancer
Abstract
We hypothesize that M2 macrophages also support chemotherapy resistance by interacting with tumor-initiating cells. With this proposal, we aim to thoroughly investigate the influence of M2 macrophages on ovarian tumor initiating cells. To do so, we will combine the chemotherapy drug paclitaxel with a CSF1R inhibitor to block M2macrophages. Using three models of ovarian cancer: a mouse model, a human cell line implanted into mice, and samples of human ovarian cancer implanted into mice, we will study M2 macrophages and tumor-initiating cells during chemotherapy treatment. We will further explore how interactions between M2 macrophages and tumor-initiating cells support chemoresistance by disrupting M2 macrophages with CSF1R inhibition. We expect that combination therapy of CSF1R inhibition and paclitaxel will render the ovarian tumor-initiating cells more sensitive to chemotherapy treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1136193
Entities
People
- Lily Wu
Organizations
- University of California, Los Angeles