RBPJ and EphrinB2 as Molecular Targets to Treat Brain Arteriovenous Malformation in Notch4-Induced Mouse Models

Abstract

The overall project focuses on elucidating the cell signaling that drives structural changes in brain blood vessels that lead to the formation of arterio-venous malformations, with Prof. Rong Wang (UCSF) as the scientific lead. Prof. Chris Schaffer's lab (Cornell) contributes to this work by helping Prof Wang's laboratory maintain the necessary in vivo imaging capabilities at UCSF and by developing more advanced imaging capabilities that would allow a finer dissection of the cellular interactions that underlie the vascular changes.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1138307

Entities

People

  • Chris B. Schaffer
  • Rong Wong

Organizations

  • Meinig School of Biomedical Engineering

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Blood
  • Blood Flow
  • Cardiovascular Physiological Phenomena
  • Cells
  • Central Nervous System
  • Data Analysis
  • Detection
  • Engineering
  • Experimental Design
  • Lasers
  • Lymphocytes
  • Nervous System
  • Optics
  • Scattering
  • Spinal Cord

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Research Science/Academic Research