Notch3 as a Tumor Suppressor in the Postpartum Mammary Gland
Abstract
The goal of this project is to determine the functions of Notch3 in the pathogenesis of postpartum breast cancer, focusing on the regulation of parity-induced mammary epithelial cells, as we as regulation of brown adipose tissue repopulation in the postpartum mammary gland and its potential role in modulating tumor microenvironment. We showed that parous Notch3 mutant glands exhibited an expansion of CD24HiCD49fLo cells, a subpopulation known to be enriched in bipotent lobule progenitors and multipotent stem cells, associated with upregulation of Gata3. Unexpectedly, we found that Notch3 knockout mice suppressed mammary tumor xenografts. We identified candidates of Notch3 target genes in immune cells that may regulate tumor-immune interaction. Our results suggest that Notch3 functions as a tumor suppressor in the mammary epithelium and brown adipocytes in the postpartum mammary gland while exerting an oncogenic role in the immune system.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2021
- Accession Number
- AD1138333
Entities
People
- Keli Xu
Organizations
- University of Mississippi