Scalability and Safety Studies in Clinical-Grade Pluripotent-Derived Myogenic Progenitors for Therapeutic Application in DMD

Abstract

During the second year of this grant, we finalized optimization of the CD54+ MACS-purification protocol (in vitro and in vivo validation) as well as completed the growth curve studies as well as the in vivo experiments using the optimized media composition. Whole genome sequencing and mapping of integration sites has also been achieved.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2021
Accession Number
AD1139896

Entities

People

  • David Mckenna
  • Rita Perlingeiro

Organizations

  • Regents of the University of Minnesota

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Cells
  • Culture Techniques
  • Demographic Cohorts
  • Intramuscular Injections
  • Law
  • Minnesota
  • Muscle Fibers
  • Muscles
  • Professional Development
  • Scalability
  • Skeletal Muscle
  • Standards
  • Stem Cells
  • Technology Transfer
  • Universities
  • Validation

Fields of Study

  • Biology

Readers

  • Clinical Trial Research.
  • Molecular Genetics
  • Molecular and Cellular Biology