Mismatch Repair Loss Renders ER+/HER2- Breast Cancer Susceptible to HER2/3 Inhibition

Abstract

The objective of this proposed study is to investigate a role for HER2/3 activation in MutLdefective ER+ breast cancer progression and resistance to endocrine therapy. By targeting HER2/3 signaling and key nodes of adaptive kinome response, we aim to significantly improve patient disease-specific survival.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2021
Accession Number
AD1139897

Entities

People

  • Svasti Haricharan

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Breast Cancer
  • Clinical Trials
  • Department Of Defense
  • Diseases And Disorders
  • Growth Factors
  • Inhibition
  • Inhibitors
  • Maryland
  • Neoplasms
  • Patent Applications
  • Professional Development
  • Resistance
  • Students
  • Technology Transfer
  • Training

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.
  • Neural Network Machine Learning.