Effectiveness of Trauma Management Therapy and Prolonged Exposure Therapy for the Treatment of Post-Traumatic Stress Disorder in an Active Duty Sample: A Comparison Study

Abstract

This study will provide an evaluation of performance and suitability of the compressed versions of exposure psychotherapy to support the capability gap for the treatment of active-duty service members and veterans with PTSD by comparing different exposure psychotherapy modalities. The overall objective of this study is to determine if compressed psychotherapy can be used as an effective alternative treatment for PTSD and to compare the impact of TMT and PE on social, familial, and occupational impairment. The primary objectives will be to compare 1) 3-week TMT with 12-week PE and 2) 3-week TMT with 2-week PE for the effectiveness of reducing PTSD symptoms in a gated approach or some other method to control for multiplicity. Outcomes will be determined based upon self-report, clinician ratings, as well as other aspects of psychopathology, and social/emotional functioning. The addition of the TMT group component will be assessed in particular to determine its impact on social, familial, and occupational impairment. The current status of the software and VR suite as a potential FDA-regulated medical device needs to be evaluated. The investigator or the company/supplier should request an IDE exemption for the study from the FDA. Blood samples will be collected from participants at baseline and at the end of the treatment period in order to identify PTSD biomarkers, e.g., predictors of response, biological subtypes of PTSD, and therapeutic markers. Collection, storage, and transfer of the blood samples to DoD will be performed according to standardized protocols provided by the DoD. One or more site visits may occur in order to assess adherence to standardized protocols.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2021
Accession Number
AD1139906

Entities

People

  • Deborah C. Beidel

Organizations

  • University of Central Florida Board of Trustees

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Active Duty
  • Anxiety Disorders
  • Biomedical Research
  • Computational Biology
  • Contractors
  • Contracts
  • Data Analysis
  • Department Of Defense
  • Diseases And Disorders
  • Governments
  • Health Care
  • Health Services
  • Management Personnel
  • Medical Personnel
  • Systems Biology
  • Traumatic Stress Disorder
  • Virtual Reality

Fields of Study

  • Medicine
  • Psychology

Readers

  • Clinical Trial Research.
  • Marine Propulsion Engineering and Naval Architecture
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.