Role of p53 and PAI-1 in Tobacco Smoke Induced Lung Injury

Abstract

Chronic exposure to tobacco smoke (TSE) causes irritation of and damage to the lung epithelium. This can lead to chronic obstructive pulmonary disease (COPD), the third leading cause of death in the United States. In COPD, chronic inflammation leads to alveolar wall destruction leading to emphysema. Recent literature clearly suggest that telomere dysfunction is a determinant of emphysema susceptibility in mice and humans. Further, telomere dysfunction due to TSE induces replicative senescence and death of progenitor type II alveolar epithelial cells (A2Cs) leading to alveolar wall damage and alveolar injury.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2021
Accession Number
AD1139943

Entities

People

  • Sreerama Shetty

Organizations

  • University of Texas at Austin

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Atomization
  • Biological Aging
  • Biomedical Research
  • Carrier Proteins
  • Chromosome Structures
  • Department Of Defense
  • Diseases And Disorders
  • Dysfunction
  • Emphysema
  • Epithelial Cells
  • Lung Diseases
  • Maryland
  • Medical Personnel
  • Professional Development
  • Proteins
  • United States

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