Using High-Precision Signaling Activity Imaging to Personalize Ras Pathway Inhibition Strategies in Neurofibromatosis

Abstract

The goal of this project was to characterize differences in Ras pathway signaling, using live cell activitymeasurements in cell types and genetic contexts relevant to NF1. This final report includes three publications arisingfrom our study, along with a summary of our findings and research products. The results presented herein provide arationale, based on the characteristics of ERK activity at the single-cell level, for treatment of patients carrying NF1mutations by sustained, long-term inhibition of ERK pathway activity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1141227

Entities

People

  • Carolyn Teragawa
  • Heather Blizard
  • John G Albeck
  • Michael Pargett
  • Taryn Gillies

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Computational Science
  • Culture Techniques
  • Data Science
  • Gene Expression
  • Genetics
  • Image Processing
  • Indicator Dyes
  • Information Processing
  • Information Science
  • Medical Personnel
  • Neuromuscular Diseases
  • Peptide Growth Factors
  • Proteins
  • Statistical Algorithms
  • Statistical Analysis
  • Stem Cells
  • Systems Biology

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Technical Research and Report Writing.

Technology Areas

  • Biotechnology