Evaluation of the Effects of High Level Overpressure (8+psi) on Cognitive Performance, Brain Blood Biomarkers and Symptom Reporting
Abstract
This is a multi-site observational study of military and law enforcement personnel who are exposed to overpressure (OP) where data is collected in conjunction with occupational training exercises. The studys primary purpose is to characterize a variety of weapon systems/environments (OP, impulse, acoustics) and measure effects (neurocognitive, biomarkers, symptom reporting, etc.) immediately after OP exposure (< 5 min)and/or at end of training day (i.e., acute effects). 2 data collections took place (n1 = 15, n2 = 15 at2 different sites. Sensor orientation, position, and distance from the blast source are necessary details for sufficiently interpreting occupational blast exposure. Blast exposure levels are affected by a variety of factors; tactical methods and weapon suppressors may mitigate overpressure and acoustic exposures, whereas helmet shape may increase exposure due to an under-wash effect. Overpressure and acoustic exposure levels measured in a low overpressure blast environment were associated with neurocognitive deficits. Changes were identified in blood-based biomarkers (targeted proteins, DNA methylation) after repeated blast overpressure exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2021
- Accession Number
- AD1141228
Entities
People
- Walter S. Carr
Organizations
- Geneva Foundation