Exosome Therapy for Stabilization of Extremity Injury
Abstract
Cellular therapies have tremendous potential for the successful treatment of major extremity wounds in the combat setting; however, the challenges associated with transplanting stem cells in the prolonged field care (PFC) environment are a critical barrier to progress intreating such injuries. Our goal is develop a new strategy utilizing extracellular vesicles (EVs) secreted by stem cells that can resolve many of these issues. Aim 1 of the project is to determine the optimal dosage and storage conditions of lyophilized extracellular vesicles(EVs) for enhancing cell survival in an in vitro model of muscle ischemia. Aim 2 will determine the impact of EV treatment on tissue preservation and recovery utilizing in vivo models of hindlimb ischemia-reperfusion injury. The proposed research, by advancing stem cellEV therapy, will therefore serve the public purpose by addressing the healthcare needs of not only active duty military personnel, their families, and veterans, but also civilians for whom ischemic injury is a major cause of morbidity and mortality.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2021
- Accession Number
- AD1142153
Entities
People
- Mark W Hamrick
Organizations
- Augusta University