Uncovering New Therapeutics and Neuroprotective Mechanisms for TBI

Abstract

During the reporting period, we find that TBI induced changes in sleep are not related to TBI induced mortality with similar changes observed between flies that die and do not. We used high speed video analysis to resolve at high resolution the locomotor impairments induced ina dose-dependent manner by TBI. We discovered a role for antimicrobial peptides (AMPs) in mediating TBI effects on sleep where loss of AMPs alters the TBI induced effects on sleep(increased versus reduced in control flies). Importantly, these studies reveal molecular effectors of TBI effects highlighting the role of innate immunity and inflammation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2021
Accession Number
AD1142156

Entities

People

  • Ravi Allada

Organizations

  • Northwestern University

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Infective Agents
  • Autism
  • Bacterial Infections And Mycoses
  • Biological Therapy
  • Biomedical Research
  • Brain Injuries
  • Circadian Rhythms
  • Climbing
  • Diptera
  • Diseases And Disorders
  • Drosophila
  • Genetics
  • Medical Personnel
  • Monitoring
  • Peptides
  • Sleep Disorders
  • Standards
  • Students
  • Therapy

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.