Advancing Rehabilitation: Physiological, Psychological and Neuroimaging Measures of Factors that Predispose, Promote, and Perpetuate Post-Traumatic Dizziness
Abstract
The annual incidence of mild traumatic brain injury (mTBI or concussion) among the US general public is about 1:150; among military personneldeployed in combat it is about 1:5. Dizziness is one of the most disabling symptoms reported by the 10-20 of individuals who experience a prolonged recoveryfollowing mTBI. Research to date has failed to identify the pathophysiological processes underlying persistent post-mTBI vestibular symptoms in the majority ofpatients. Identifiable structural damage to the vestibular labyrinth or brain accounts for only a small fraction of cases. This study will investigate the development ofpost-mTBI dizziness using recent insights and methods derived from studies of chronic dizziness that develops after non-traumatic events, employing the vestibulardisorder of persistent postural-perceptual dizziness as a model. The study will examine 60 patients at a post-acute time point (2-8 weeks after injury) and again at achronic time point (6-8 months after injury) using a combination of physiological, psychological, and advanced structural and functional neuroimaging techniques.An additional 24 patients will be examined at the chronic time point and all patients will be matched to health volunteers for cross sectional and longitudinalcomparisons. The specific aims are to elucidate mechanisms of persistent dizziness and identify early predictive factors that may be utilized clinically to triage at-riskindividuals to needed treatment as early as possible after mTBI.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1143200
Entities
People
- Jeffrey P Staab
Organizations
- Mayo Clinic