PI3K Signaling in Tumor Cells and Stroma Regulates Breast Cancer Metastasis
Abstract
Breast cancer is a major public health problem in the United States, and the American Cancer Society estimates that 40,000 women died from this disease in 2017. Tumor metastasis is the major cause of mortality in human breast cancer, and effective treatment of metastatic disease will require a better understanding of the signaling mechanisms that drive breast cancer cell invasion (the ability of tumor cells to move away from the primary tumor and into surrounding tissue). Our data suggests that a specific type of phosphoinositide 3-kinase, called PI3Kb, is strongly implicated in breast cancer metastasis. This proposal examines how PI3Kb regulates both tumor cells and the immune cells that modulate tumor cell behavior, leading to increased metastasis. Our study could establish PI3Kb as an important new drug target for the treatment of metastatic disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2021
- Accession Number
- AD1143202
Entities
People
- Jonathan M Backer
Organizations
- Albert Einstein College of Medicine