Nano-pulsed Laser Optoacoustic Therapy for Pre-treatment and Post-treatment of Traumatic Brain Injury
Abstract
Traumatic brain injury (TBI) represents both an acute and a chronic medical challenge among service members and veterans. The purpose of this research is to demonstrate, in a rodent model, that a unique non-invasive nano-pulsed laser optoacoustic therapy (NPLT) is a promising pre-treatment for military personnel at high risk of combat-related TBI and a promising treatment after combat-related TBI, with the goal of limiting onset and progression of neuropathology and cognitive impairment. During the first year of this grant (10/01/19-09/30/20), we have prepared and submitted the animal protocol to USAMRDC Animal Care and Use Review Office (ACURO) and after receiving approval on January 10, 2020, we have completed the behavioral experiments for Aim 1 and found that pre-treatment with NPLT reduces cognitive impairments in the rats subjected to blast-induced brain injury. We have additionally initiated histopathological analyses for Aim 1 and behavioral testing for Aim 2 as originally planned in the approved proposal.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1143206
Entities
People
- Maria-adelaide Micci
Organizations
- University of Texas Medical Branch