A Multi-Omics Approach to Overcome Resistance in Infant Leukemia by Identifying Immune Therapy Failure Mechanisms

Abstract

Despite advances in curing children over 1 year of age with acute lymphoblastic leukemia (ALL) children under 1 year of age face grim survival rates of around 35%. Infants with ALL often experience on therapy relapses. Bone marrow transplant has persistently failed to improved outcomes. The goal of this proposal is to use a single cell multi-omic approach to better understand the biology of infant ALL, particularly with respect to immune mechanisms, as a prerequisite to develop better therapies including novel immunotherapy approaches.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2021
Accession Number
AD1143208

Entities

People

  • Erin Guest
  • Kathrin M. Bernt
  • Patrick Brown

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Bone Marrow
  • Cells
  • Computer Programming
  • Data Analysis
  • Department Of Defense
  • Failure Mode And Effect Analysis
  • Governments
  • Humanities
  • Immunotherapy
  • Lymphocytes
  • Medical Personnel
  • Professional Development
  • Resistance
  • Students
  • Therapy
  • Training

Fields of Study

  • Biology
  • Medicine

Readers

  • Educational Psychology
  • Oncology

Technology Areas

  • Biotechnology