Hybrid Bone-Tendon Grafts for Enhanced Tendon Healing
Abstract
This proposal addresses the Surgical Care Focus Area of Soft Tissue Trauma. Over 200,000 rotator cuff surgeries are performed annually in the United States alone with an estimated cost of $3.44 billion USD. Rotator cuff injuries in the active military present unique challenges because traumatic or repetitive overhead injuries are inherent with the job description. Re-tear rates after rotator cuff repair ranges from 20% to 94% due to a combination of factors, including age, tissue quality, tear size, fatty infiltration of the associated rotator cuff muscles, and biological healing response at the bone-tendon interface. Commercially available tissue augmentation grafts had been attempted in the past, with unpredictable results. While the underlying reasons for this lack of efficacy vary, materials and devices that mimic the features of native tissues are expected to improve clinical outcomes. Research efforts have focused primarily on the development of materials to sustain physiological loading and the administration of biochemical cues to direct healing. However, there has been a paucity of literature in reestablishing native bone to tendon interface and multi-tissue continuity. More specifically, no previous studies have simultaneously demonstrated synthetic or native tissue derived tendon grafts with approximation of bone and tendon mechanical properties, spatial control of musculoskeletaldifferentiation, and physicochemical features for structural continuity and integrity. Rotator cuff injury in active service members continues to be a clinically significant problem.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2021
- Accession Number
- AD1144346
Entities
People
- Yunzhi P. Yang
Organizations
- Stanford University