Isoflurane as an Accurate Negative Mode Calibrant for Ion Mobility Spectrometry
Abstract
The search for suitable ion mobility spectrometry (IMS) calibrant compounds is ongoing and neccesitates the use of highly accurate reduced ion mobility (K0) values across a range of instrumental conditions. Such values will be used in calibrating devices to shift the ion mobility scales and alarm windows for chemicals of interest to their proper locations, based on the instrumental conditions present during calibration and sampling. Many positive ion mode calibrants have been investigated, whereas investigations for a negative ion detection mode calibrant have been more limited. Isoflurane (IsoF) is a strong candidate as a negative ion mode calibrant. This report documents the accurately measured K0 values for IsoF product ions as a function of multiple instrumental parameters. K0 values were measured in two instrumentation modes as a function of drift gas temperature, water concentration, and dopant concentration. This report culminates with our evaluation of the suitability of IsoF as a negative ion mode calibrant for IMS applications.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2021
- Accession Number
- AD1144683
Entities
People
- Brian C Hauck
- Charles S. Harden
- Vincent M. Mchugh