Role of Matrix Metalloproteinase-3 in Deployment-Related Pulmonary Fibrosis
Abstract
We have demonstrated that exposure of mice to silicate-containing PM induces pulmonary fibrosis with initial inflammation in the terminal bronchioles and alveolar ducts followed by collagen deposition. We have demonstrated that human alveolar macrophages respond to inhaled particulate matter by producing an array of inflammatory and fibrogenic mediators that likely contribute to the respiratory symptoms and clinical illness frequently observed in military personnel previously deployed to Southwest Asia and Afghanistan. We have demonstrated the feasibility of engineering highly selective TIMP-based MMP inhibitors by yeast surface display. We expect this result to impact the field of protein engineering. Our efforts to uncover the sequence and structural determinants responsible for improvements in TIMP-1 selectivity will also impact the understanding of protein-protein interactions and binding specificity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2020
- Accession Number
- AD1145728
Entities
People
- Derek C. Radisky
- Gregory P. Downey
Organizations
- National Jewish Health