A Milk Protein-Hitchhiking Strategy for the Oral Delivery of Amphiphilic Vaccines
Abstract
We are grateful for this Discovery award to enable an oral vaccine delivery platform against infectious diseases. Following the last report, we have performed in vitro and in vivo experiments according to the original SOW. While we are encouraged by in vitro data we have obtained over the past year, to date our progress has been primarily hindered by the low efficacy in vivo. To address the lack of efficacy in vivo, we have made extensive efforts in two major directions: (1) development of an in vitro gut model to understand the transport properties of amphiphilic peptides; (2) identification of a more potent adjuvant system targeting the STING pathway to augment the in vivo performance. The latter effort has resulted in one manuscript recommended for publication pending a minor revision at Advanced Therapeutics. We are hopeful that with the new adjuvant system we would be able to induce immune responses following oral vaccination.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2021
- Accession Number
- AD1145922
Entities
People
- Jiahe Li
Organizations
- Northeastern University