Utilizing a Shape Memory Polymer Scaffold to Evaluate Three Tissue Sources of Mesenchymal Stromal Cells in a Rat Calvarial Defect

Abstract

Combat and trauma can result in massive bone loss, which pose significant challenges to healing. Autografting remains the gold standard of treatment for critical size defects; however, risks include donor site morbidity and limited availability. An alternative is allografts but they are suboptimal as they have reduced osteo-inductive capabilities. We propose a cell/biomaterial-based therapy to improve bone healing with adipose (ADSC), bone marrow (BMSC), or umbilical cord (UCSC) derived human mesenchymal stromal cells (MSCs) in a novel poly(sigma-caprolactone) shape memory polymer (SMP) scaffold coated with polydopamine. The benefits of this scaffold include the ability to custom fit into irregularly shaped defects and a slow degradation profile that supports bone growth. This study aims to determine if MSCs are most effective in their pre-differentiated or undifferentiated state and compare the cell source with a novel SMP scaffold.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1146845

Entities

People

  • Alexander J. Burdette
  • Bridney Lundquist
  • Heuy-ching Wang
  • Jessica M. Shah
  • Joseph Macaitis
  • Melissa A Grunlan
  • Wen Lien

Organizations

  • 59th Medical Wing
  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Air Force
  • Biomedical Research
  • Bone Marrow
  • Bones
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Fetus
  • Governments
  • National Governments
  • Osteoblasts
  • Osteogenesis
  • Osteoporosis
  • Polymers
  • Stromal Cells
  • United States
  • United States Government
  • Universities

Readers

  • Computational Modeling and Simulation
  • Immunology and Pathology
  • Nanoscale Plasmonic Nanotechnology