Comparison of Different Resuscitation Fluids (Hydroxocobalamin vs. Whole Blood vs. Lactated Ringers) Over Time in Volume Controlled and Uncontrolled Hemorrhage Models in Swine (Sus scrofa)

Abstract

Traumatic hemorrhage is the leading cause of preventable death in civilian and military environments. Blood components are frequently unavailable in the prehospital setting due to increased costs and lack of resources, training and viable portable refrigeration. Hydroxocobalamin (HOC), a synthetic form of vitamin B12, works as an antidote for cyanide toxicity and increases blood pressure via nitric oxide scavenging.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2021
Accession Number
AD1146893

Entities

People

  • Dylan Rodriguez
  • Joseph K Maddry
  • Kaysie Canellis
  • Kimberly Medellin
  • Maria Castaneda
  • Normalynn Garrett
  • R Parades
  • Susan Boudreau

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Blood Gases
  • Blood Volume
  • Cardiovascular Physiological Phenomena
  • Department Of Defense
  • Hemorrhage
  • Hemorrhagic Shock
  • Laboratory Animals
  • Statistical Analysis
  • Volume

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry
  • Neurotrauma and Rehabilitation Medicine.