Corticosteroid Eluting Endotracheal Tube to Mitigate Airway Inflammation Associated with COVID-19

Abstract

A drug-eluting endotracheal tube (ET) that reduces inflammation in injured laryngotracheal tissues will be evaluated. The ET will deliver dexamethasone, hydroxychloroquine, antivirals (valacyclovir), Roxadustat (FG-4592),and anti-SMAD3 siRNA using a polymer mesh coated ET-Tube in an animal model. Optimized dosing and response data across variables will be established.

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Document Details

Document Type
Technical Report
Publication Date
Jul 28, 2020
Accession Number
AD1146903

Entities

People

  • Diana V. Del Monaco

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Airway Management
  • Clinical Trials
  • Covid-19
  • Department Of Defense
  • Diseases And Disorders
  • Governments
  • Infectious Diseases
  • Inflammation
  • Intubation
  • Operational Readiness
  • Project Management
  • Therapy
  • Virus Diseases
  • Wound Healing

Fields of Study

  • Medicine

Readers

  • Electronics Engineering
  • Immunology and Pathology