A Time-Dependent Physiological Model of Innate and Adaptive Immune Responses Activated by Superficial Thermal Burns
Abstract
The physiological mechanisms activated in response to first degree (superficial) thermal burns follow the normal progression of wound healing, which is comprised of four distinct yet overlapping phases. In this work, a time-dependent physiological model (TDPM) governed by 22 ordinary differential equations is formulated to capture both hematopoietic and immunologic events across the bone marrow, lymphatic tissues, blood vessels and local wound site. As superficial thermal injuries do not disrupt hematopoietic homeostasis, the model reduces to a subsystem describing innate and adaptive immune dynamics as well as early fibroblast activity at the injury site. Numerical simulations are then conducted to assess the models capability to reproduce known and feasible biological behavior. The TDPM will later serve as a foundational structure for the construction of physiologically driven models that leverage legacy models developed by the Defense Threat Reduction Agency (DTRA) to predict casualty distributions after a nuclear detonation (NUDET) event.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2022
- Accession Number
- AD1147050
Entities
People
- Amy Creel
- Angela Reynolds
- Rachel Jennings
Organizations
- Applied Research Associates (United States)