Pharmacological Enhancement of Cortical Activity for Controlling Chronic Pain
Abstract
Chronic pain is a major problem of public health in both civilians and military personnel. Patients with neuropathic pain often experience severe pain that is often refractory to current treatment options. The goal of this research proposal is to develop a new treat mentoption by enhancing the activity of nerve cells in the related areas of the brain. Specifically, we will test a compound that are known to mildly enhance neuronal activity in the brain. In a nerve injury model in mice, we will determine whether the drugs will reduce pain sensation to mechanical stimulation and spontaneous pain. Then we will use imaging techniques to examine activities of the whole cerebral cortex in live animals. We also record electrical activity from single brain neurons to understand how the drugs affect single neurons and the input they receive from synapses. Findings from this study have the potential to open new avenues for pain treatment and to limit the amount of medication that is needed for effective pain relief. We expect that this study will contribute to better patient care and reduce the use of opioids and its lethal side-effects in soldiers and veterans.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1148558
Entities
People
- Xiaoming Jin