Torsion-Induced Traumatic Optic Neuropathy (TITON): Animal Model for Diagnostics, Drug Delivery, and Therapeutics for Injuries to the Central Nervous System

Abstract

Deployment-related injuries to the central nervous system (CNS) have increased in frequency since World War II. The increasingly frequent use of improvised explosive devices over the past decade has dramatically increased the rate of these injuries. Unfortunately, rapid diagnosis of these injuries during the window of opportunity for significant CNS regeneration remains problematic. Further, no treatments have yet been developed to the point of clinical applicability which successfully regenerate CNS tissues. We have therefore developed and will use a unique and novel animal model of traumatic optic neuropathy (TON) which allows ready access to the central nervous system for studies on CNS regeneration.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2021
Accession Number
AD1148559

Entities

People

  • Colleen Cebulla
  • Julie Racine
  • Katelyn E. Swindle-reilly
  • Matthew A. Reilly
  • Mohamed H Abdel-Rahman

Organizations

  • Ohio State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Calcium Compounds
  • Cell Physiological Processes
  • Central Nervous System
  • Chemistry
  • Engineering
  • Governments
  • Health Services
  • Mechanical Properties
  • Mechanics
  • Medical Personnel
  • Nervous System
  • Optic Nerve
  • Shear Stresses
  • Students
  • Test Methods
  • Therapy

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.