Evaluation of Alternative Splicing Regulators as Targets for Selective Therapy of Triple-Negative (Basal) Breast Carcinoma

Abstract

The goal of this proposal was to evaluate the role of splicing regulators upregulated in triple negative breast cancer in the tumorigenesis process and identify potential therapeutic targets. We previously identified three splicing factors, SRPK1, KHDRBS3 and SRSF12, that were expressed at higher levels in triple negative breast cancer compared to other breast cancer subtypes. We proposed to evaluate these splicing factors for their ability to support the tumorigenic properties of basal type breast cancer cells, and the formation of tumors in mouse model of triple negative breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2020
Accession Number
AD1148560

Entities

People

  • Peter Stoilov

Organizations

  • West Virginia University

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Bone Marrow
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Movement
  • Cells
  • Experimental Design
  • Gene Expression
  • Genes
  • Genetics
  • Immune System
  • Luminescence
  • Mammary Glands
  • Neoplasms
  • Proteins

Readers

  • Molecular Biology and Genetics
  • Oncology