Immunologic Mechanisms for Heterogeneity of Cutaneous Lupus Erythematosus
Abstract
Our goal is to understand the biologic determinants in newly diagnosed patients with discoid lupus erythematosus who then do not respond to anti-malarials. Understanding the molecular and cellular basis for the heterogeneity of responses to treatment will aid in the appropriate selection of patients for a given treatment and potentially indicate new therapeutic targets. Phosphorylated STING and NFkB are higher in HCQ+QC-responders, and we have performed sub-analyses demonstrating a correlation between pSTING and IFN, as well as increased cDC-labeled pSTING and IFN further verified by in situhybridization studies. In addition, the numbers of T regulatory were lower in antimalarial-refractory than QC-responsive patients. With the advent of new therapies such as STING inhibitors and other therapies that boost T regulatory cells, the studies will aid in subsetting patients for evaluation for future therapeutic interventions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1148567
Entities
People
- Victoria Werth