Molecular Mechanisms of Transcription Factor Dosage in Heart Development and Congenital Heart Disease

Abstract

We have discovered that we can indeed understand molecular mechanisms of Congenital Heart Disease using cultured pluripotent stem cells when differentiated to cardiac cells. This requires the study of thousands of single cells rather than the whole population. These results will help us understand what type of cell is most affected upon loss of the congenital heart disease gene TBX5. Our findings in mice are also pointing a specific cell type within the developing heart that is most relevant to congenital heart disease.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2021
Accession Number
AD1148569

Entities

People

  • Benoit Bruneau

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Boundaries
  • Cells
  • Congenital Heart Defects
  • Diseases And Disorders
  • Electrophysiology
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Genetic Structures
  • Genetics
  • Genomics
  • Heart Diseases
  • Medical Personnel
  • Molecules
  • Pregnancy Complications
  • Regulations
  • Stem Cells
  • Transcription Factors

Fields of Study

  • Biology
  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Immunology

Technology Areas

  • Biotechnology