A Randomized, Prospective, Within-Patient, Controlled Clinical Study to Investigate Full Thickness Skin Tissue Columns as a Novel Skin Replacement Therapy
Abstract
Orthogonal skin harvest is a novel technique to obtain donor skin in the form of tissue columns for skin replacement. The transfer of full-thickness skin elements in columnar bits to a recipient wound bed may result in more functional skin and less donor site morbidity than conventional, tangentially-harvested, split-thickness skin grafts. In this study, we propose to evaluate and compare tissue columns obtained from an FDA-cleared device, ART(trademark)(Autologous Regeneration of Tissue), to split-thickness skin grafts obtained from a conventional skin dermatome in a prospective, randomized, within-patient, controlled study to determine quality and speed of healing, as well as the need for re-grafting and donor site morbidity. The use of skin tissue columns as donor skin grafts presents a new paradigm for skin replacement, and this study is an important step to understanding how skin columns fit into our current surgical armamentarium for patients who have open wounds from surgery, trauma or burns.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1148584
Entities
People
- Rodney K Chan
- Victoria Diaz