Implantation of Full Thickness Skin Columns to Decrease Hypertrophic Scar Formation After Deep Partial Thickness Burns

Abstract

PURPOSE: The purpose of this study is to provide proof-of-concept, pre-clinical evidence for use of autologous full-thickness skin column implantation for the treatment of deep partial-thickness burn injury to prevent hypertrophic scar formation. This evidence will support a pivot into clinical trials of this strategy. OBJECTIVES: The long-term objective is to develop autologous full-thickness skin column implantation as an improved, low morbidity methodology for the treatment of deep partial-thickness burn. The scientific objective of this proposal is to evaluate the early (pre-epithelialization) and late (post-epithelialization) efficacy of three different seeding ratios of implanted full-thickness skin columns in reducing hypertrophic scar formation by accelerating wound closure, improving skin quality parameters, reducing wound contraction and minimizing donor-site morbidity in a porcine model of deep partial thickness burn.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2021
Accession Number
AD1148589

Entities

People

  • Anders H Carlsson
  • Rodney K Chan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood Flow
  • Burns
  • Cardiovascular Physiological Processes
  • Clinical Trials
  • Combat Injuries
  • Contracts
  • Covid-19
  • Data Analysis
  • Department Of Defense
  • Electronic Mail
  • Histology
  • Implantation
  • Medical Personnel
  • Military Medicine
  • Morbidity
  • Patent Applications
  • Professional Development
  • Skin Grafts
  • Technology Transfer
  • Training

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.