Quantitative Assessment of Post-traumatic Osteoarthritis by Multi-modal Optical Coherence Tomography
Abstract
Evidence from osteoarthritis (OA) studies suggests that there is a narrow time window in theearly stages of the disease when cartilage can be functionally restored to reduce furtherdegeneration. Small internal cartilage damages due to traumatic joint injuries are hard todetect with the traditional imaging technologies but pose a significant risk of inducing OAlater. Our goal is to develop a non-destructive and label-free combination of opticalcoherence tomography (OCT) based methods for early detection of PTOA by assessment ofmechanical strength, which is dependent upon both GAG and collagen, through our novel methodfor optical coherence elastography (OCE) based on fringe washout, and of collagen by itselfthrough polarization-sensitive OCT. While our progress has been slowed by the current COVID19 pandemic, we have demonstrated, for the first time to our knowledge, volumetric assessmentof the mechanical properties of cartilage and bone. We anticipate successful completion ofour aims as our campus re-opens for research activities. This work will provide the firstoptical method capable of complete non-destructive assessment of sub-surface cartilagedegeneration for PTOA diagnosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2021
- Accession Number
- AD1148600
Entities
People
- B. H. Park
- Jin Nam
Organizations
- University of California, Riverside