Cathartocytosis: A Novel Cellular Process Essential for Metaplastic Dedifferentiation
Abstract
I have discovered that the epitope recognized by mAb Das-1 and which is aberrantly expressed in foregut metaplasia and cancer is 3-Sulfo-LeA. The manuscript describing these findings has been uploaded to BioRXIV and revisions have been submitted to Scientific Reports. Based on this knowledge we have made significant progress in molecularly characterizing the process of cathartocytosis annotated by this antigen. Our studies have also suggested that this epitope may actually play a functional role in cathartocytosis and thus inhibiting its synthesis in high-risk metaplasia and cancer from synthesizing this antigen may have therapeutic potential for esophageal, gastric, and pancreatic cancer. I were happy with the progress during the first year of this grant and I am sure I will have more exciting findings to report over the next two years. In addition to these discoveries, I have also published 4 additional primary research papers, 2 abstracts, given an oral presentation at Digestive Disease Week, and received three additional smaller grants. Support from this grant has been acknowledged where appropriate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2021
- Accession Number
- AD1148763
Entities
People
- Jeffrey W Brown
Organizations
- Washington University in St. Louis