Treatment of Verbal Retrieval Deficits in Mild Traumatic Brain Injury with High Definition Transcranial Direct Current Stimulation

Abstract

The study examines the use of HD tDCS targeting preSMA to treat word retrieval deficits in combat veterans who have suffered TBI. Qualifying participants are randomly assigned to receive 15 sessions of active tDCS (1 milliamp for 20 minutes) or sham tDCS on a schedule of 1 per day. Then, following 2- and 3-month follow-up assessments, sham participants are invited to participate in second phase of 15 active tDCS treatment sessions. At the conclusion of this study, we will have established the effectiveness of HD tDCS as a non-pharmacologic treatment for improving verbal retrieval in patients with combat related TBI. Additionally, we propose to be able to 1) classify patterns of mTBI in order to optimize HD tDCS treatment strategies, and 2) use changes in EEG as objective outcome measures of brain impairment after mild TBI and recovery of function following HD tDCS treatment. We have established the research team, laboratory setting, and recruiting procedures, and obtained approval of all regulatory documents for the study. We screened several potential participants in the past month, and recruited our first participant to complete pre-treatment assessments in September.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2021
Accession Number
AD1149443

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  • John Jr Hart

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  • University of Texas at Dallas

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  • Biomedical

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  • Clinical Trial Research.
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.