Development of a Single Animal Dynamic Airflow Whole-Body Exposure Apparatus
Abstract
Commercially available whole-body (WB) aerosol exposure chambers are typically designed to house groups of small- to medium-sized animals or single large animals. These chambers range in size, generally from 250 to 1000 L; are constructed of stainless steel and glass and polycarbonate; and require dedicated laboratory space and ventilation for operation. The WB plethysmograph offered by several commercial manufacturers is often used as a small WB exposure chamber. A recent study in our laboratory required the use of a WB exposure system that would allow for easy observation of animal behaviors and have the capability to collect data from implanted telemetry devices and resistance to decontamination solutions. Commercially available products do not meet all of these requirements; therefore, a system was designed to meet them. Herein, we describe the design, construction, and optimization of a single animal WB exposure apparatus for small- to medium-sized animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2021
- Accession Number
- AD1149558
Entities
People
- Chelsea R. Boeri
- Dennis B. Miller
- Michael S. Horsmon
- Ronald A. Evans
- Theodore S. Moran