Multi-site confirmatory efficacy treatment trial of PTSD

Abstract

The present study is a multisite trial with randomization of 330 OEF/OIF/OND veterans with combat related post-traumatic stress disorder (PTSD) to one of three treatment arms 1 Hz repetitive transcranial magnetic stimulation (rTMS) to the right frontal dorsal lateral prefrontal cortex (rDLPFC) alone, 1 Hz rDLPFC rTMS Cognitive Processing Therapy (CPT), or sham rTMS CPT to determine which of these treatments is most effective for reducing PTSD symptoms, as measured by the CAPS-5, and PCL-5.We have established the research team, laboratory setting, maintained approval of all regulatory documents for all performance locations for the study, and established recruiting procedures. We have recruited 131 subjects for the study and enrolled 37 out of 330 subjects in the baseline testing and treatment phase of the study.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2021
Accession Number
AD1149896

Entities

People

  • John Jr Hart

Organizations

  • University of Texas at Dallas

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anxiety Disorders
  • Biomedical Research
  • Cognition
  • Covid-19
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Health Services
  • Information Operations
  • Internet
  • Intervention
  • Maryland
  • Medical Personnel
  • Monitoring
  • Patent Applications
  • Professional Development
  • Recruiting
  • Social Media
  • Technology Transfer
  • Test Methods
  • Traumatic Stress Disorder
  • Universities

Fields of Study

  • Psychology

Readers

  • Clinical Trial Research.
  • Neuroscience
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.