Epigenomic Landscape of Primary Prostate Cancer in African American Men

Abstract

We hypothesize that differences in the epigenomic landscape may interact with somatic genomic alterations and tumor microenvironment to drive racial disparities in prostate cancer outcomes and that epigenomic alterations may serve as prognostic molecular biomarkers in AA PCa. Here, we propose to conduct the largest study to comprehensively define the epigenomic landscape of PCa arising in AA men with long-term oncologic follow-up and/or tumor somatic sequencing and immune microenvironment characterization. This research will identify unique epigenomic drivers of aggressive biology and adverse PCa outcomes among AA patients, elucidating novel biological underpinnings of this critical health care disparity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2021
Accession Number
AD1149981

Entities

People

  • Tamara L Lotan

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • African Americans
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Gene Expression
  • Genes
  • Genetics
  • Health Care
  • Health Services
  • Medical Personnel
  • Minority Groups
  • Neoplasms
  • Prostate Cancer

Fields of Study

  • Biology

Readers

  • Oncology
  • Prostate Cancer Biology.