Targeting Drivers of Aggressive Triple-Negative Breast Cancer in African Americans

Abstract

Triple-negative breast cancer (TNBC) is an overly aggressive breast cancer subtype that disproportionately affects African American women. In our preliminary studies, we found that p53 mutations in TNBC often coincided with deletion/silencing of the CDKN2A locus that encodes both the ARF and INK4A tumor suppressors. The purpose of this study is to investigate the potential of targeting JAK1 (through loss of p53 and ARF) and CDK4 (through INK4A loss) activity in treating TNBC and the biomarkers predictive of response. In this project period, we have been focusing on the construction of our Tissue Microarray (TMA). We have reviewed 377 of our 525 desired cases, and have succeeded in placing 180 case specimens in the TMA. We anticipate the completion of the TMA sample collection in the next six months.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2021
Accession Number
AD1151195

Entities

People

  • Cynthia Ma

Organizations

  • Washington University in St. Louis

Tags

DTIC Thesaurus Topics

  • Abstracts
  • African Americans
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Construction
  • Department Of Defense
  • Electronic Mail
  • Immunohistochemistry
  • Information Operations
  • Inhibitors
  • Instructors
  • Law
  • Maryland
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Patent Applications
  • Professional Development
  • Students
  • Suppressors
  • Targeting
  • Technology Transfer
  • Universities
  • Xenografts

Readers

  • Educational Psychology
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.