In Silico and In Vitro Toxicity Testing of the Novel Energetic 1-(5 tetrazolyl)-4-guanyltetrazene hydrate (Tetrazene, TTZ)

Abstract

This study evaluated the toxicity of 1-(5-tetrazolyl)-4-guanyltetrazene (tetrazene, TTZ) in several in vitro test systems, including the Ames mutagenicity assay, the Microtox Acute Toxicity Test System, and a skin sensitization tiered prediction model utilizing h-CLAT and DPRA. Data from the h-CLAT were also utilized to predict a Hazard Category (United Nations Economic Commission for Europe (UNECE) 2015) for acute oral toxicity. Data from this study are used to assist in making environment and health-based decisions regarding the design and selection of formulas and materials for further development of new munition compounds.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2020
Accession Number
AD1151836

Entities

People

  • Emily N. Reinke
  • Valerie H. Adams

Organizations

  • United States Army Public Health Command

Tags

DTIC Thesaurus Topics

  • Albumins
  • Ammunition
  • Anti-Bacterial Agents
  • Bacteria
  • Cells
  • Data Analysis
  • Databases
  • Environment
  • Environmental Protection
  • Escherichia Coli
  • Fish
  • Groundwater
  • Instructions
  • International Organizations
  • Liquid Chromatography
  • Materials
  • Medical Personnel
  • Microsomes
  • Munitions
  • Public Health
  • Range Finding
  • Risk Analysis
  • Test Methods
  • Toxicity

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology