Anesthetic Management of Catecholaminergic Polymorphic Ventricular Tachycardia in Pregnancy

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare familial or de novo mutation in either the cardiac RyR2 Ryanodine gene (CPVT1) or CASQ2 calsequestrin gene (CPVT2). Both of these mutations alter normal cardiac myocyte calcium regulation, enhancing the propensity of sarcoplasmic reticulum calcium to be released. These spontaneous calcium discharges cause unpredictable malignant arrhythmias presenting as syncope or sudden cardiac death.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2021
Accession Number
AD1151857

Entities

People

  • Christopher J. Nagy
  • Courtney R. Hood

Organizations

  • 59th Medical Wing

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Anesthesia
  • Cardiac Arrest
  • Cardiac Arrhythmias
  • Catecholamines
  • Department Of Defense
  • Diseases And Disorders
  • Education
  • Epinephrine
  • Gene Therapy
  • Mutations
  • Norepinephrine
  • Pathophysiology
  • Pregnancy
  • Telemetry
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biology