Compliance and Performance Characteristics of Subject Collected Versus Health-care Worker Collected Nasal Swabs for Respiratory Viral Surveillance
Abstract
Background. At home, self-collection of nasal swabs (SCNS) by subjects during an influenza-like illness (ILI), is a convenient alternative to healthcare worker-collected swabs (HCWC) for PCR detection of respiratory pathogens. Unsupervised SCNS and completion of symptom-based questionnaires benefit surveillance studies by reducing clinic staffing needs, study budgets and increasing the convenience of study participation. In addition, SCNS can reduce delays in swab collection after symptom onset, since subjects do not have to visit a research facility for HCWC. We utilized a cohort of adult US Military Health System (MHS) beneficiaries enrolled in a flu vaccine effectiveness trial (PAIVED) between 2019-2020 to evaluate the following: Compliance with SCNS and HCWC swabs, Time from symptom onset to SCNS and HCWC collection, and PCR detection of viral respiratory pathogens in SCNC vs. HCWC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2021
- Accession Number
- AD1151879
Entities
People
- Ana E. Markelz
- Anthony C. Fries
- Anuradha Ganesan
- Bruce Mcclenathan
- Casey Geaney
- Catherine Skerrett
- Christian L. Coles
- Christina Schofield
- Christina Spooner
- David E. Hrncir
- Gregory Utz
- Jay R. Montgomery
- Jitendrakumar R. Modi
- Katrin Mende
- Limone Collins
- Michelle Kautz
- Nusrat J Epsi
- Rhonda E. Colombo
- Ryan Maves
- Srihari Seshadri
- Stephanie A Richard
- Tahaniyat Lalani
- Timothy H. Burgess
Organizations
- 59th Medical Wing